Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc.

161.08
USD
+1.19
(+0.74%)
19.78EPS
12.06P/E
33.03BMarket Cap
Feb 18Next Earn
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
0.77
0.68
0.49
0.55
0.99
0.74
2.01
4.29
7.13
8.53
14.64
17.61
28.35
37.65
Basic EPS, GAAP
-1.45
-4.85
-3.45
-4.79
-5.42
-7.57
-8.11
-7.46
-7.2
-9.3
-3.52
-2.18
2.39
20.46
Free Cash Flow per Basic Share
-1.18
-2.35
-2.41
-4.35
-5.38
-6.85
-3.83
-5.96
-6.06
-5.04
0.34
-0.33
3.55
5.65
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
4.24
12.13
14.86
10.71
17.72
12.87
12.82
8.73
4.89
-1.28
-1.75
0.52
5.96
26.92
Tangible Book Value per Share
4.24
12.13
14.86
10.71
17.72
12.87
12.82
8.73
4.89
-1.28
-1.75
0.52
5.96
26.92
Basic Weighted Avg Shares
62
74
84
86
91
101
109
115
118
122
125
128
131
133
Sales/Revenue/Turnover
47
51
41
47
90
75
220
493
844
1,037
1,828
2,248
3,714
5,013
Operating Margin (%)
-197.05
-364.34
-720.27
-900.33
-556.2
-1,087.56
-427.5
-168.09
-83.93
-75.68
-15.43
-7.87
13.51
19.5
Depreciation Expense
10
12
19
15
12
15
54
74
90
44
54
57
56
55
Net Income, GAAP
-89
-360
-290
-410
-491
-761
-886
-858
-853
-1,131
-440
-278
314
2,724
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
2.91
- -
Profit Margin (%)
-189.17
-712.79
-705.83
-869.63
-545.95
-1,016.58
-403.24
-174.15
-101.01
-109.04
-24.08
-12.37
8.45
54.34
Working Capital
200
651
1,043
540
1,620
1,021
1,363
2,030
2,113
1,924
2,015
2,109
2,584
3,050
LT Debt
- -
- -
- -
150
30
30
276
484
957
1,278
1,264
1,254
1,233
854
Total Equity
270
936
1,265
920
1,766
1,302
1,439
1,016
588
-158
-221
67
789
3,604
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
28.39
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
32.59
- -
Return on Common Equity (%)
-44.13
-59.74
-26.36
-37.54
-36.54
-49.63
-64.66
-69.92
-106.31
- -
- -
- -
73.28
141.97

Capital Structure

USD

•

in mil. unless spec.
Mar'26
Jun'26
Sep'26
ST Debt
46
46
408
LT Borrowings
1,009
1,011
651
LT Finance Leases
218
210
203
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
133
134
134
Market Capitalization
44,153
40,258
33,032

Working Capital

USD

•

in mil. unless spec.
Mar'26
Jun'26
Sep'26
Total Current Assets
4,219
4,620
5,113
Cash, Cash Equivalents & STI
3,009
3,308
3,587
Accounts Receivable, Net
884
913
1,085
Inventories
84
97
106
Total Current Liabilities
1,349
1,513
2,063
Payables & Accruals
1,073
1,204
1,372
ST Debt
46
46
408
Deferred Revenue
3
4
12

Growth Rates

USD

•

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
83.59%
163.27%
1,076.33%
Free Cash Flow
-132.99%
-302.18%
-1,192.73%
Net Income, GAAP
-14.93%
-55.74%
-212.79%
Sales/Revenue/Turnover
66.49%
51.72%
65.19%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

USD

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
494
660
501
593
2,248
2025
594
774
1,249
1,097
3,714
2026
1,167
1,291
1,458
- -
- -

Quarterly Earnings Per Share

USD

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.52
-0.13
-0.87
-0.65
-2.18
2025
-0.14
-0.55
2.23
1.41
2.39
2026
1.55
1.23
16.19
- -
- -

Quarterly Dividends Per Share

USD

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

CEO
Yvonne L. Greenstreet
Full Time Employees
2,500
Sector
Health technology
Industry
Pharmaceuticals: major
Address
675 West Kendall Street Cambridge MA United States 02142
IPO Date
May 28, 2004
Business
Alnylam Pharmaceuticals, Inc. (ALNY) develops and commercializes RNA interference (RNAi) therapeutics targeting genetically defined diseases; core products include ONPATTRO (patisiran) for hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy, AMVUTTRA (vutrisiran) for ATTR amyloidosis with polyneuropathy or cardiomyopathy, GIVLAARI (givosiran) for acute hepatic porphyria, and OXLUMO (lumasiran) for primary hyperoxaluria type 1; the company also advances partnered programs such as Leqvio (inclisiran) for hypercholesterolemia marketed by Novartis. Founded in 2002 and headquartered in Cambridge, Massachusetts, Alnylam operates globally with key facilities in the US, Europe (including France, Italy, Netherlands, Sweden, Switzerland, and the UK), and Japan. The company maintains strategic collaborations with Roche on zilebesiran for hypertension, Regeneron for CNS diseases, Sanofi on fitusiran for hemophilia, and others including Novartis and Agios Pharmaceuticals. Recent developments encompass expansion of AMVUTTRA into ATTR cardiomyopathy with strong launch uptake and upgraded 2025 revenue guidance, initiation of a Phase 1 trial for ALN-4324 targeting GRB14 for type 2 diabetes, and Agios' IND clearance for AG-236 (ALN-TMP) in polycythemia vera; Alnylam joined the Alliance for Genomic Discovery in 2025 to leverage datasets for gene-silencing medicines and extended its partnership with Medison Pharma into LATAM and APAC markets. Pipeline advancements feature nucresiran for ATTR amyloidosis, mivelsiran for Alzheimer's disease and cerebral amyloid angiopathy, and positive Phase 3 data for zilebesiran. These efforts support Alnylam's transition to profitability with 2024 net product revenues exceeding $1.3 billion across rare and cardiometabolic indications.

Company News

  • Alnylam Announces $1 Billion Share Repurchase Program and Change in Commercial Leadership

  • Alnylam to Present Five-Year HELIOS-B Data and Expanding Evidence on the Benefits of RNAi-Powered TTR Silencing with AMVUTTRA® (vutrisiran) at AHA and ISA 2026

  • Buy, Sell, or Hold? Today’s Top Upgrades and Downgrades: Amazon.com, Coinbase Global, CrowdStrike, FormFactor, GameStop, L3Harris Technologies, Oracle, Reddit, Rivian Automotive, and More

  • ALNY Stock Down 25% Despite Q3 Earnings Beat on Demand Growth Concerns

  • Lost Money on Alnylam Pharmaceuticals, Inc. Stock? Glancy Prongay Wolke & Rotter LLP Continues Investigating Possible Securities Fraud After 28.31% Share Price Drop

  • Alnylam Pharmaceuticals, Inc. (ALNY) Q3 2026 Earnings Call Transcript

  • Alnylam Pharmaceuticals Q3 Earnings Call Highlights

  • Alnylam Pharmaceuticals (ALNY) Q3 Earnings and Revenues Top Estimates

  • Compared to Estimates, Alnylam (ALNY) Q3 Earnings: A Look at Key Metrics

  • Alnylam Pharmaceuticals Reports Third Quarter 2026 Financial Results and Highlights Recent Period Progress

  • Alnylam (ALNY) Q3 Earnings on the Horizon: Analysts' Insights on Key Performance Measures

  • Alnylam Pharmaceuticals, Inc. (ALNY) RNAi Roundtable: Exon 1 Targeting With Brezosiran for Huntington's Disease Transcript

  • Alnylam Reports Up to 83% Huntingtin Reduction, Eyes 2027 Pivotal Trial

  • Alnylam: Amvuttra Growth And Brezosiran Strengthen The Bull Case

  • Alnylam Announces Positive Initial Phase 1b Data for Brezosiran (ALN-HTT02) Demonstrating Deep and Durable Huntingtin Lowering in Huntington's Disease

  • Alnylam Announces Positive Initial Phase 1b Data for Brezosiran (ALN-HTT02) Demonstrating Deep and Durable Huntingtin Lowering in Huntington's Disease

  • Alnylam Pharmaceuticals (ALNY) Expected to Beat Earnings Estimates: Can the Stock Move Higher?

  • Alnylam Is Now Solidly Profitable. Why Are Investors Treating It Like a Broken Biotech?

  • 34,533 Alnylam Pharmaceuticals, Inc. $ALNY Shares Sold by Curated Wealth Partners LLC

  • Alnylam Pharmaceuticals, Inc. $ALNY Shares Newly Acquired by First Citizens Bank & Trust Co.